應(yīng)材料與化學(xué)學(xué)院婁筱叮教授的邀請(qǐng),澳大利亞墨爾本樂(lè)卓博大學(xué)高級(jí)講師,博導(dǎo)洪煜檸到我校做學(xué)術(shù)報(bào)告。
報(bào)告題目:Molecular Reporters for Measuring Proteome Stress in Cells
報(bào)告時(shí)間:6月11日(本周二)上午10:30
報(bào)告地點(diǎn):學(xué)海樓109報(bào)告廳
Abstract:
Maintaining proteostasis is an essential housekeeping function for cell survival. It involves chaperones and degradative pathways to ensure proteins fold correctly and to remove those that are misfolded, damaged or aggregated. In principle, proteostasis is affected in any disease that involves misfolded or mutant proteins that do not fold with normal efficiencies; and hence overdraw on the finite proteostasis resources of the cell. Tracking the proteostasis capacity of cells has the generic potential to track neurodegenerative diseases with diverse specific molecular origins. Hence, building new approaches to identify the efficiency of proteostasis is highly desired in order to track the risk of cells succumbing to damage from protein misfolding and aggregation. In this seminar, I will introduce the new probes and methodology we developed for reporting the changes in protein conformation and modifications resulting from collapse of proteostasis capacity in cells under stress and how we made use of these probes in different models.
Short Bio:
洪煜檸,2006年獲中山大學(xué)應(yīng)用化學(xué)學(xué)士,2011年獲香港科技大學(xué)納米科學(xué)與技術(shù)哲學(xué)博士,師從唐本忠院士。2011-2012年間于美國(guó)達(dá)特茅斯大學(xué)從事博士后研究,2012-2014年間受聘于香港科技大學(xué)化學(xué)系與高等研究院任職研究助理教授,2014年入選澳大利亞墨爾本大學(xué)McKenzie Fellow, 2016年至今受聘于澳大利亞墨爾本樂(lè)卓博大學(xué)(La Trobe University)任職高級(jí)講師,博導(dǎo)。2017年獲得澳大利亞國(guó)家研究理事會(huì)杰出青年基金項(xiàng)目資助(ARC DECRA),2018年獲得澳大利亞皇家化學(xué)會(huì)Rita Cornforth Lectureship Award。洪煜檸課題組主要從事化學(xué)生物學(xué)交叉學(xué)科研究和探索,通過(guò)設(shè)計(jì)聚集誘導(dǎo)發(fā)光分子并結(jié)合各種熒光成像手段,研究蛋白質(zhì)錯(cuò)誤折疊與疾病的關(guān)系。已公開(kāi)發(fā)表SCI收錄學(xué)術(shù)論文90余篇,包括J. Am. Chem. Soc., Nat. Commun., Chem. Soc. Rev.等雜志,論文他引一萬(wàn)余次,H-index 40,獲授權(quán)美國(guó)專(zhuān)利9項(xiàng)。
歡迎全校師生參加!
材料與化學(xué)學(xué)院
納米礦物材料及應(yīng)用教育部工程研究中心
2019/6/10
